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KMID : 1143620160200020036
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Korean Journal of Nuclear Medicine Technology
2016 Volume.20 No. 2 p.36 ~ p.41
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Evaluation on the Usefulness of Alternative Radiopharmaceutical by Particle size in Sentinel Lymphoscintigraphy
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Jo Gwang-Mo
Jeong Yeong-Hwan
Choi Do-Chul
Shin Ju-Cheol
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Abstract
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Purpose : Sentinel lymphoscintigraphy (SLS) was using only 99mTc-phytate. If the supply is interrupted temporarily, there
is no alternative radiopharmaceuticals. The aim of this study measure the particle size of radiopharmaceuticals and look for radiopharmaceuticals which can be substituted for 99mTc-phytate.
Materials and Methods : The particle size of radiopharmaceuticals were analyzed by a nano-particle analyzer. This study were selected known radiopharmaceuticals to be useful particle size for SLS. We were divided into control and experimental groups using 99mTc-DPD, 99mTc-MAG3, 99mTc-DMSA with 99mTc-phytate. For in-vivo experiment, radiopharmaceuticals were injected intradermally at both foot to perform lymphoscintigraphy. Imaging was acquired to dynamic and delayed static image and observe the inguinal lymph nodes with the naked eye.
Results : Particle size was measured respectively Phytate 105~255 nm (81.9%), MAG3 91~255 nm (98.7%), DPD 105~342 nm (77.3%), DMSA 164~ 342 nm (99.2%), MAA 1281~2305 nm (90.6%), DTPA 342~1106 nm (79.4%), and HDP 295~955 nm (94%). In-vivo delayed static image, inguinal lymph nodes of all experiment groups and two control groups are visible to naked eye. however, 99mTc-MAG3 of control groups is not visible to naked eye.
Conclusion : We were analyzed to the particle size of the radiopharmaceuticals that are used in in-vivo. Consequently, 99mTc-DPD, 99mTc-DMSA are possible in an alternative radiopharmaceuticals of emergency.
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KEYWORD
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Particle size, 99mTc-phytate, Sentinel Lymphoscintigraphy
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